Stephen F Traynelis Selected Research

Ionotropic Glutamate Receptors

1/2018	A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.
1/2017	Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.
1/2017	Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.
1/2017	Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.

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Stephen F Traynelis Research Topics

Disease

14	Epilepsy (Aura) 01/2021 - 01/2014
13	Nervous System Diseases (Neurological Disorders) 10/2021 - 07/2004
9	Brain Diseases (Brain Disorder) 01/2021 - 01/2014
7	Parkinson Disease (Parkinson's Disease) 01/2018 - 09/2007
6	Intellectual Disability (Idiocy) 01/2020 - 07/2015
6	Schizophrenia (Dementia Praecox) 01/2019 - 07/2015
5	Seizures (Absence Seizure) 01/2021 - 10/2016
5	Inflammation (Inflammations) 08/2014 - 10/2007
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 09/2007
4	Neurodevelopmental Disorders 01/2021 - 10/2016
4	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 11/2012
3	Autism Spectrum Disorder 01/2020 - 10/2016
3	Stroke (Strokes) 01/2019 - 01/2015
3	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2017 - 09/2004
3	Ischemia 12/2015 - 05/2009
3	Brain Injuries (Brain Injury) 08/2011 - 09/2004
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2019 - 10/2016
2	Autistic Disorder (Autism) 12/2017 - 07/2015
2	Neuroinflammatory Diseases 08/2014 - 05/2013
2	Gliosis 09/2007 - 04/2005
2	Brain Ischemia (Cerebral Ischemia) 09/2004 - 10/2003
1	Malformations of Cortical Development 04/2022
1	Muscle Hypotonia (Hypotonia) 01/2020
1	Central Nervous System Diseases (CNS Diseases) 01/2019
1	Partial Epilepsies (Epilepsy, Partial) 07/2018
1	Aphasia (Dysphasia) 07/2018
1	Polymicrogyria 01/2018
1	Ischemic Stroke 01/2017
1	Mood Disorders (Mood Disorder) 01/2017
1	Mental Disorders (Mental Disorder) 01/2017
1	Status Epilepticus (Complex Partial Status Epilepticus) 10/2016
1	Neoplasms (Cancer) 10/2016
1	Glioma (Gliomas) 10/2016
1	Learning Disabilities (Learning Disability) 10/2016
1	Dementia (Dementias) 01/2016
1	Rare Diseases (Rare Disease) 11/2014
1	Smith-Magenis Syndrome 11/2014
1	Sepsis (Septicemia) 08/2014
1	Pain (Aches) 11/2012
1	Neuralgia (Stump Neuralgia) 10/2010
1	Glioblastoma (Glioblastoma Multiforme) 02/2010
1	Encephalitis (Encephalitis, Rasmussen) 07/2009
1	Spinal Cord Injuries (Spinal Cord Injury) 05/2009
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 05/2009
1	Memory Disorders (Memory Loss) 10/2007
1	Thrombosis (Thrombus) 05/2007

Drug/Important Bio-Agent (IBA)

30	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 04/2022 - 09/2005
4	N-Methylaspartate (NMDA)IBA 01/2019 - 09/2005
4	LigandsIBA 01/2018 - 01/2014
4	Ionotropic Glutamate ReceptorsIBA 01/2018 - 01/2017
4	Serine Proteases (Serine Protease)IBA 05/2009 - 07/2004
4	Peptide Hydrolases (Proteases)FDA Link 05/2009 - 09/2004
3	Ligand-Gated Ion ChannelsIBA 10/2021 - 01/2014
3	Glutamic Acid (Glutamate)FDA Link 07/2018 - 11/2014
3	Proteinase-Activated ReceptorsIBA 05/2009 - 05/2007
2	Pharmaceutical PreparationsIBA 01/2021 - 01/2020
2	AcidsIBA 01/2020 - 07/2015
2	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 09/2007
2	2- (2- furanyl)- 7- (2- (4- (4- (2- methoxyethoxy)phenyl)- 1- piperazinyl)ethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo(1,5- c)pyrimidine- 5- amineIBA 01/2016 - 08/2014
2	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2016 - 07/2014
2	Ion Channels (Ion Channel)IBA 01/2015 - 03/2014
2	PAR-1 ReceptorIBA 09/2007 - 10/2003
1	Biological ProductsIBA 01/2020
1	Pentylenetetrazole (Metrazol)IBA 01/2020
1	Protons (Proton)IBA 01/2019
1	Guanylate KinasesIBA 12/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	Anticonvulsants (Antiepileptic Drugs)IBA 10/2016
1	Ketamine FDA LinkGeneric 10/2016
1	MagnesiumIBA 10/2016
1	Peptides (Polypeptides)IBA 01/2016
1	Amyloid (Amyloid Fibrils)IBA 01/2016
1	GABA Receptors (GABA Receptor)IBA 07/2015
1	Kainic Acid Receptors (Kainate Receptor)IBA 07/2015
1	Cycloserine (Seromycin)FDA Link 01/2015
1	Nonsense Codon (Nonsense Mutation)IBA 11/2014
1	LipopolysaccharidesIBA 08/2014
1	Green Fluorescent ProteinsIBA 07/2014
1	Adenosine A2 Receptor AntagonistsIBA 07/2014
1	Memantine (Namenda)FDA Link 03/2014
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 05/2013
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 02/2010
1	Inositol (Myoinositol)IBA 02/2010
1	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA 02/2010
1	CalciumIBA 02/2010
1	Caffeine (No Doz)FDA LinkGeneric 02/2010
1	Adenosine Triphosphate (ATP)IBA 07/2009
1	Adenosine (Adenocard)FDA LinkGeneric 07/2009
1	Fibrinolysin FDA Link 05/2009
1	Dizocilpine Maleate (Dizocilpine)IBA 05/2009
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 09/2007
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 09/2007
1	Thrombin Receptors (Thrombin Receptor)IBA 04/2005
1	Thrombin FDA Link 04/2005
1	Glucose (Dextrose)FDA LinkGeneric 09/2004

Therapy/Procedure

5	Therapeutics 01/2020 - 02/2010
3	Precision Medicine 10/2019 - 10/2016
1	Electrodes (Electrode) 01/2018
1	Lasers (Laser) 08/2014
1	Laser Therapy (Surgery, Laser) 08/2014